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Cat. No. Product Name Target Signaling Pathways
T36982 CXCR3 Antagonist 6c

CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM). 1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial eva...
T38160 STING Agonist 1a

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T83926 S-Geranylgeranyl-L-glutathione

GGG

S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体(GPCR)P2RY8的配体。该化合物在100 nM浓度下,选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2(S1P2)、GPR55、半胱氨酸白三烯受体1CysLT1 receptor)以及CysLT2 receptor的内吞作用。在10 nM浓度下,S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子(C-X-C motif)配体12(CXCL12)诱导的迁移。
T36461 CAY10748

CAY10748

CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...
T35463 (±)14(15)-EET

(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T83841 STING Agonist D61

D61,Stimulator of Interferon Genes Agonist D61

STING激动剂D61(D61)是干扰素基因刺激剂(STING)的激动剂。它在基于细胞的分析中诱导IFN3诱导的分泌性碱性磷酸酶(SEAP)报告基因和IFN-β诱导的报告基因的表达(EC50分别为52.9和116 nM)。D61(4, 6, 和8 µM)增加了编码IFN-β和化学因子(C-X-C基序)配体10(CXCL10)的mRNA的表达以及TANK结合激酶1(TBK1)、IRF3和STING在THP-1单核细胞中的磷酸化。在体内,D61(每隔一天0.25 mg/kg)在CT26小鼠结肠癌模型中减少肿瘤体积,而不影响体重。
T83779 EP4 Antagonist 14

Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

EP4 antagonist 14是一种前列腺素E2(PGE2)受体亚型EP4的拮抗剂,其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募(IC50 = 0.9 nM)。EP4 antagonist 14(10 µM)能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达,这些mRNA编码Il-4、巨噬细胞甘露糖受体1(Mrc1)、几丁质酶样蛋白3(Chil3)、趋化因子(C-X-C)基序配体1Cxcl1)、表达在髓样细胞上的触发受体2(Trem2)和精氨酸酶-1(Arg1)。在体内,EP4 antagonist 14(每天30 mg/kg),结合抗PD-1抗体,能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。
T37289 Resolvin D2 n-3 DPA

Resolvin D2 n-3 DPA

Resolvin D2 n-3 DPA (RvD2 n-3 DPA) is a specialized pro-resolving mediator (SPM).1It is formed from docosapentaenoic acid , an intermediate in the conversion of eicosapentaenoic acid to docosahexaenoic acid , in human leukocytes. RvD2 n-3 DPA (1 nM) reduces TNF-α-induced chemotaxis and adhesion of isolated human neutrophils.In vivo, RvD2 n-3 DPA (100 ng/animal; i.v.) reduces peritoneal neutrophil infiltration and exudate levels of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in a mouse model o...

化合物

CXCR3 Antagonist 6c
Cat.No: T36982
Synonym:
Target:
STING Agonist 1a
Cat.No: T38160
Synonym:
Target:
S-Geranylgeranyl-L-glutathione
Cat.No: T83926
Synonym: GGG
Target:
CAY10748
Cat.No: T36461
Synonym: CAY10748
Target:
(±)14(15)-EET
Cat.No: T35463
Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
Target:
STING Agonist D61
Cat.No: T83841
Synonym: D61,Stimulator of Interferon Genes Agonist D61
Target:
EP4 Antagonist 14
Cat.No: T83779
Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
Target:
Resolvin D2 n-3 DPA
Cat.No: T37289
Synonym: Resolvin D2 n-3 DPA
Target:
Cat. No. Product Name Species Expression System
TMPY-04037 MIP-1 alpha/CCL3 Protein, Rat, Recombinant

chemokine (C-

Rat E. coli
CCL3 is a cytokine belonging to the CC chemokine family. Chemokines are a family of structurally related leukocyte chemoattractant cytokines that play a central role during immunoregulatory and inflammation processes. All chemokines contain four conserved cysteines linked by disulfide bonds, and two major subfamilies, namely CXC and CC, are defined on the basis of the first two cysteines which are separated by one amino acid or are adjacent. CCL3 is involved in the acute inflammatory state in th...
TMPY-00695 I-309 Protein, Human, Recombinant (hFc)

chemokine (C-

Human HEK293
CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferatio...
TMPY-00649 MIP-1 alpha/CCL3 Protein, Human, Recombinant (His)

LD78α,chemokine (C

Human Yeast
CCL3 is a cytokine belonging to the CC chemokine family. Chemokines are a family of structurally related leukocyte chemoattractant cytokines that play a central role during immunoregulatory and inflammation processes. All chemokines contain four conserved cysteines linked by disulfide bonds, and two major subfamilies, namely CXC and CC, are defined on the basis of the first two cysteines which are separated by one amino acid or are adjacent. CCL3 is involved in the acute inflammatory state in th...
TMPY-02820 SDF-1 Protein, Human, Recombinant (isoform a)

SDF1,chemokine (...

Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; C...
TMPY-00740 SDF-1 Protein, Human, Recombinant (hFc)

PBSF,IRH,chemokine (C

Human HEK293
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; C...
TMPY-02591 SDF-1 Protein, Human, Recombinant

SDF1,chemokine (...

Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; C...
TMPY-00118 MCP-1/CCL2 Protein, Human, Recombinant (His)

SCYA2,HC11<...

Human Yeast
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted The...
TMPY-00566 CCL18 Protein, Human, Recombinant (His)

PARC,CC

Human Yeast
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-04726 IL-8/CXCL8 Protein, Human, Recombinant (His)

Interleukin-8,GCP1,MONAP,LE

Human Yeast
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is...
TMPY-02970 CXCL10 Protein, Human, Recombinant

IFI10,IP-10,chemokin...

Human E. coli
(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic ...
TMPY-00472 IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)

NAF,GCP1,NAP1,

Human E. coli
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is...
TMPY-00754 IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)

MONAP,MDNCF,NAP-1,白介素,NAP1

Human HEK293
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is...
TMPY-03905 Lymphotactin/XCL1 Protein, Canine, Recombinant (His)

chemokine (C

Canine Baculovirus-Insect Cells
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.Cancer ImmunotherapyImmune CheckpointImm...
TMPY-02755 Lymphotactin/XCL1 Protein, Cynomolgus, Recombinant (His)

chemokine (C

Cynomolgus Baculovirus-Insect Cells
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.Cancer ImmunotherapyImmune CheckpointImm...
TMPY-04713 Fractalkine Protein, Cynomolgus, Rhesus, Recombinant (His)

chemokine (C-X3...

Cynomolgus,Rhesus HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-02415 Fractalkine Protein, Cynomolgus, Rhesus, Recombinant (hFc)

chemokine (C-X3...

Cynomolgus,Rhesus HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-03897 Fractalkine Protein, Canine, Recombinant (hFc)

chemokine (C-X3...

Canine HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-04665 Fractalkine Protein, Canine, Recombinant (His)

chemokine (C-X3...

Canine HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-03898 Fractalkine Protein, Canine, Recombinant

chemokine (C-X3...

Canine HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-00305 MDC Protein, Mouse, Recombinant (His)

DCBCK,MDC

Mouse E. coli
Chemokine (C-C motif) ligand 22(ABCD-1 / CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory processes. The cytokine displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. This ABCD-1 / CCL22 chemokine...
TMPY-00008 CXCL1 Protein, Rat, Recombinant

chemokine (C-X-...

Rat E. coli
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-03728 CCL28 Protein, Human, Recombinant (His)

MEC,SCYA28,c...

Human E. coli
CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR10 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and lactating mammary gland as well. Besides, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues an...
TMPY-02125 CCL6 Protein, Mouse, Recombinant (His)

Scya6,MRP-1,c

Mouse HEK293
Chemokine (C-C motif) ligand 6 (CCL6), also known as C-C chemokine C10 has only been identified in rodents, which is a small cytokine belonging to the CC chemokine family, beta-chemokine subfamily. C-C chemokine C10 is involved in the chronic stages of host defense reactions. C10 chemokine rapidly promotes disease resolution in the cecal ligation and puncture (CLP) model through its direct effects on the cellular events critically involved in host defense during septic peritonitis. CCL6 appears ...
TMPY-02538 I-309 Protein, Mouse, Recombinant (hFc)

BF534335,chemokine (C

Mouse HEK293
CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferatio...
TMPY-04984 CXCL17 Protein, Human, Recombinant (His)

Dcip1,UNQ473,DMC

Human Yeast
Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski...
TMPY-03071 I-309 Protein, Human, Recombinant

SISe,P500,TCA3,I-309,c

Human E. coli
CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferatio...
TMPY-05353 CCL26 Protein, Human, Recombinant

MIP-4alpha,SCYA26,MIP-4a,c

Human Baculovirus-Insect Cells
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3), which is also expressed by several different cell types, including basophils, dendritic cells, smooth muscle cells, epithelial cells and fibroblasts. The sequence similarity between the three eotaxins is limited (<4%), but their functional properties are very similar. Eotaxin-1 ...
TMPY-02749 SDF-1 Protein, Human, Recombinant (His)

SDF1,IRH,chemokine (...

Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; C...
TMPY-00433 CXCL1 Protein, Mouse, Recombinant

Gro1,Scyb1,gro,K...

Mouse E. coli
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPJ-00831 CCL3 Protein, Mouse, Recombinant (His)

LD78 α,MIP-1 α,MIP1-a,MIP-1 alpha...

Mouse E. coli
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extra...
TMPY-04887 BCA-1 Protein, Human, Recombinant

BCA1,BCA-1<...

Human E. coli
The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid o...
TMPY-02756 MDC Protein, Human, Recombinant (His)

A-152E5.1,MDC,AB...

Human E. coli
Chemokine (C-C motif) ligand 22(ABCD-1 / CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory processes. The cytokine displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. This ABCD-1 / CCL22 chemokine...
TMPY-02610 Lymphotactin/XCL1 Protein, Mouse, Recombinant (His)

SCM-1a,AI661682,...

Mouse Baculovirus-Insect Cells
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.Cancer ImmunotherapyImmune CheckpointImm...
TMPY-02687 Lymphotactin/XCL1 Protein, Human, Recombinant (His)

SCM1,SCM-1<...

Human Baculovirus-Insect Cells
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.Cancer ImmunotherapyImmune CheckpointImm...
TMPY-02770 CCL20 Protein, Mouse, Recombinant (His)

CKb4,exodus-1,MIP-3[a],ST38,MIP3A...

Mouse Baculovirus-Insect Cells
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL20 is Expressed predominantly in the liver, ...
TMPY-04889 CCL20 Protein, Mouse, Recombinant

LARC,MIP-3A,Scya20,<...

Mouse E. coli
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL20 is Expressed predominantly in the liver, ...
TMPY-00737 Fractalkine Protein, Human, Recombinant (His)

CXC3,neurotac

Human HEK293
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
TMPY-05618 CXCL14 Protein, Human, Recombinant, Biotinylated

MIP2G,BMAC,KS1,MIP-2g,

Human E. coli
CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs). CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor...
TMPY-06582 CXCL14 Protein, Human, Recombinant (His)

SCYB14,BRAK,MIP2G,KS1,MI...

Human E. coli
CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs). CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor...
TMPY-00606 MCP-1/CCL2 Protein, Mouse, Recombinant (His)

AI323594,HC11,Sigje,M

Mouse Baculovirus-Insect Cells
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted The...
TMPY-03781 CXCL14 Protein, Human, Recombinant

SCYB14,MIP-2g,MIP2G,KS1,...

Human E. coli
CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs). CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor...
TMPY-00564 MCP-4 Protein, Human, Recombinant (His)

MCP-4,CC

Human Yeast
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem...
TMPY-05653 MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated

MCP-1,chemo...

Mouse Baculovirus-Insect Cells
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted The...
TMPY-03231 MIP-1 alpha/CCL3 Protein, Mouse, Recombinant

MIP-1α,LD78α,chemokine (...

Mouse E. coli
CCL3 is a cytokine belonging to the CC chemokine family. Chemokines are a family of structurally related leukocyte chemoattractant cytokines that play a central role during immunoregulatory and inflammation processes. All chemokines contain four conserved cysteines linked by disulfide bonds, and two major subfamilies, namely CXC and CC, are defined on the basis of the first two cysteines which are separated by one amino acid or are adjacent. CCL3 is involved in the acute inflammatory state in th...
TMPJ-00974 XCL1 Protein, Human, Recombinant (hFc & His)

Cytokine SCM-1,...

Human Human Cells
Lymphotactin is a secreted protein which belongs to the intercrine gamma family. It is also a member of the XC chemokine family. XCL1 is found in spleen with highest level, lower in peripheral leukocytes and very low levels in lung, colon and small intestine. XCL1 plays a role in inflammatory and immunological responses, inducing leukocyte migration and activation. XCL1 induces chemotactic function by binding to a chemokine receptor called XCR1. XCL1 is closely related to another chemokine calle...
TMPY-00001 CXCL14 Protein, Mouse, Recombinant

MIP2gamma,Scyb14,BMAC

Mouse E. coli
CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs). CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor...
TMPY-02868 CXCL1 Protein, Human, Recombinant

chemokine (C-X-...

Human E. coli
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-02026 CXCL1 Protein, Human, Recombinant (His & SUMO)

FSP,P450c21B,CY...

Human E. coli
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-02180 CXCL1 Protein, Human, Recombinant (His & NusA)

CA21H,CPS1<...

Human E. coli
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-00755 IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc)

chemokine (C-X-...

Human HEK293
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is...
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重组蛋白

MIP-1 alpha/CCL3 Protein, Rat, Recombinant
Cat.No: TMPY-04037
Species: Rat
Expression System: E. coli
I-309 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00695
Species: Human
Expression System: HEK293
MIP-1 alpha/CCL3 Protein, Human, Recombinant (His)
Cat.No: TMPY-00649
Species: Human
Expression System: Yeast
SDF-1 Protein, Human, Recombinant (isoform a)
Cat.No: TMPY-02820
Species: Human
Expression System: E. coli
SDF-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00740
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant
Cat.No: TMPY-02591
Species: Human
Expression System: E. coli
MCP-1/CCL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00118
Species: Human
Expression System: Yeast
CCL18 Protein, Human, Recombinant (His)
Cat.No: TMPY-00566
Species: Human
Expression System: Yeast
IL-8/CXCL8 Protein, Human, Recombinant (His)
Cat.No: TMPY-04726
Species: Human
Expression System: Yeast
CXCL10 Protein, Human, Recombinant
Cat.No: TMPY-02970
Species: Human
Expression System: E. coli
IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)
Cat.No: TMPY-00472
Species: Human
Expression System: E. coli
IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)
Cat.No: TMPY-00754
Species: Human
Expression System: HEK293
Lymphotactin/XCL1 Protein, Canine, Recombinant (His)
Cat.No: TMPY-03905
Species: Canine
Expression System: Baculovirus-Insect Cells
Lymphotactin/XCL1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-02755
Species: Cynomolgus
Expression System: Baculovirus-Insect Cells
Fractalkine Protein, Cynomolgus, Rhesus, Recombinant (His)
Cat.No: TMPY-04713
Species: Cynomolgus,Rhesus
Expression System: HEK293
Fractalkine Protein, Cynomolgus, Rhesus, Recombinant (hFc)
Cat.No: TMPY-02415
Species: Cynomolgus,Rhesus
Expression System: HEK293
Fractalkine Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-03897
Species: Canine
Expression System: HEK293
Fractalkine Protein, Canine, Recombinant (His)
Cat.No: TMPY-04665
Species: Canine
Expression System: HEK293
Fractalkine Protein, Canine, Recombinant
Cat.No: TMPY-03898
Species: Canine
Expression System: HEK293
MDC Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00305
Species: Mouse
Expression System: E. coli
CXCL1 Protein, Rat, Recombinant
Cat.No: TMPY-00008
Species: Rat
Expression System: E. coli
CCL28 Protein, Human, Recombinant (His)
Cat.No: TMPY-03728
Species: Human
Expression System: E. coli
CCL6 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02125
Species: Mouse
Expression System: HEK293
I-309 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02538
Species: Mouse
Expression System: HEK293
CXCL17 Protein, Human, Recombinant (His)
Cat.No: TMPY-04984
Species: Human
Expression System: Yeast
I-309 Protein, Human, Recombinant
Cat.No: TMPY-03071
Species: Human
Expression System: E. coli
CCL26 Protein, Human, Recombinant
Cat.No: TMPY-05353
Species: Human
Expression System: Baculovirus-Insect Cells
SDF-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02749
Species: Human
Expression System: E. coli
CXCL1 Protein, Mouse, Recombinant
Cat.No: TMPY-00433
Species: Mouse
Expression System: E. coli
CCL3 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00831
Species: Mouse
Expression System: E. coli
BCA-1 Protein, Human, Recombinant
Cat.No: TMPY-04887
Species: Human
Expression System: E. coli
MDC Protein, Human, Recombinant (His)
Cat.No: TMPY-02756
Species: Human
Expression System: E. coli
Lymphotactin/XCL1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02610
Species: Mouse
Expression System: Baculovirus-Insect Cells
Lymphotactin/XCL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02687
Species: Human
Expression System: Baculovirus-Insect Cells
CCL20 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02770
Species: Mouse
Expression System: Baculovirus-Insect Cells
CCL20 Protein, Mouse, Recombinant
Cat.No: TMPY-04889
Species: Mouse
Expression System: E. coli
Fractalkine Protein, Human, Recombinant (His)
Cat.No: TMPY-00737
Species: Human
Expression System: HEK293
CXCL14 Protein, Human, Recombinant, Biotinylated
Cat.No: TMPY-05618
Species: Human
Expression System: E. coli
CXCL14 Protein, Human, Recombinant (His)
Cat.No: TMPY-06582
Species: Human
Expression System: E. coli
MCP-1/CCL2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00606
Species: Mouse
Expression System: Baculovirus-Insect Cells
CXCL14 Protein, Human, Recombinant
Cat.No: TMPY-03781
Species: Human
Expression System: E. coli
MCP-4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00564
Species: Human
Expression System: Yeast
MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated
Cat.No: TMPY-05653
Species: Mouse
Expression System: Baculovirus-Insect Cells
MIP-1 alpha/CCL3 Protein, Mouse, Recombinant
Cat.No: TMPY-03231
Species: Mouse
Expression System: E. coli
XCL1 Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00974
Species: Human
Expression System: Human Cells
CXCL14 Protein, Mouse, Recombinant
Cat.No: TMPY-00001
Species: Mouse
Expression System: E. coli
CXCL1 Protein, Human, Recombinant
Cat.No: TMPY-02868
Species: Human
Expression System: E. coli
CXCL1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPY-02026
Species: Human
Expression System: E. coli
CXCL1 Protein, Human, Recombinant (His & NusA)
Cat.No: TMPY-02180
Species: Human
Expression System: E. coli
IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc)
Cat.No: TMPY-00755
Species: Human
Expression System: HEK293
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